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Cancer Investigation Volume 28, 2010 - Issue 9
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ORIGINAL ARTICLEClinical Translational Therapeutics

Polymorphisms in the AR and PSA Genes as Markers of Susceptibility and Aggressiveness in Prostate Cancer

Hellen KuasneDepartment of General Biology, Biological Science Center, Londrina State University, Londrina, Paraná, Brazil,
,
Iara Sant’Ana RodriguesDepartment of General Biology, Biological Science Center, Londrina State University, Londrina, Paraná, Brazil,
,
Paulo Emílio FugantiLondrina Hospital of Cancer, Londrina, Paraná, Brazil,
,
Roberta Losi-GuembarovskiDepartment of General Biology, Biological Science Center, Londrina State University, Londrina, Paraná, Brazil,
,
Kazuhiro ItoDepartment of Pathology, Health Science Center, Londrina State University, Londrina, Paraná, Brazil,
,
Marina O. KishimaDepartment of Pathology, Health Science Center, Londrina State University, Londrina, Paraná, Brazil,
,
Marco Aurélio de Freitas RodriguesDepartment of Surgery, Health Science Center, Londrina, Paraná, Brazil,
,
Silvia Regina RogattoFaculty of Medicine of Botucatu, São Paulo State University “Júlio de Mesquita Filho” – Botucatu, São Paulo, Brazil
,
Rodrigo Mattos dos SantosFaculty of Medicine of Botucatu, São Paulo State University “Júlio de Mesquita Filho” – Botucatu, São Paulo, Brazil
&
Ilce Mara de Syllos CólusDepartment of General Biology, Biological Science Center, Londrina State University, Londrina, Paraná, Brazil,Correspondence[email protected]
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Pages 917-924 | Published online: 15 Jul 2010
 
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ABSTRACT

The study of genes involved in androgen pathway can contribute to a better knowledge of prostate cancer. Our aim was to examine if polymorphisms in prostate-specific antigen (PSA) and androgen receptor (AR) genes were involved in prostate cancer risk and aggressiveness. Genotypes were determined by PCR-RFLP (PSA) or using a 377 ABI DNA Sequencer (AR). PSA(G/G) genotype (OR = 1.78, 95% CI = 1.06–2.99) and AR short CAG repeats (OR = 1.89, 95% CI = 1.21–2.96) increased risk for prostate cancer and were related with tumor aggressiveness. About 38.3% of tumors showed microsatellite instability. In conclusion, polymorphisms in these genes may be indicated as potential biomarkers for prostate cancer.

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