Advanced search
Publication Cover
Cancer Investigation Volume 28, 2010 - Issue 9
Submit an article Journal homepage
325
Views
59
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLEImaging, Diagnosis, Prognosis

A Lower Allred Score for Progesterone Receptor Is Strongly Associated With a Higher Recurrence Score of 21-Gene Assay in Breast Cancer

Ping TangDepartment of Pathology, University of Rochester of Rochester Medical Center, Rochester, New York, USA
,
Jianmin WangRTI Health Solution, Research Triangle Park, North Carolina, USA
,
David G. HicksDepartment of Pathology, University of Rochester of Rochester Medical Center, Rochester, New York, USA
,
Xi WangDepartment of Pathology, University of Rochester of Rochester Medical Center, Rochester, New York, USA
,
Linda SchiffhauerDepartment of Pathology, University of Rochester of Rochester Medical Center, Rochester, New York, USA
,
Loralee McMahonDepartment of Pathology, University of Rochester of Rochester Medical Center, Rochester, New York, USA
,
Qi YangDepartment of Pathology, University of Rochester of Rochester Medical Center, Rochester, New York, USA
,
Michelle ShayneDepartment of Pathology, University of Rochester of Rochester Medical Center, Rochester, New York, USA
,
Alissa HustonDepartment of Pathology, University of Rochester of Rochester Medical Center, Rochester, New York, USA
,
Kristin A. SkinnerDepartment of Pathology, University of Rochester of Rochester Medical Center, Rochester, New York, USA
,
Jennifer GriggsDepartment of Medicine, University of Michigan, Ann Arbor, Michigan, USA
&
Gary LymanDepartment of Medicine, Duke University School of Medicine, Durham, North Carolina, USA
 show all
Pages 978-982 | Published online: 06 Aug 2010
 
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

ABSTRACT

Among the 77 infiltrating breast carcinomas, we found that progesterone receptor (PR) expression was inversely associated with recurrence score (RS, p < .0001). RS is also significantly associated with tubule formation, mitosis, and luminal B subtype. The equation of RS = 17.489 + 2.071 (tubal formation) + 2.926 (mitosis) –2.408 (PR) –1.061 (HER2) + 7.051 (luminal A) + 29.172 (luminal B) predicts RS with an R2 of 0.65. In conclusion, PR negativity, luminal B subtype, tubal formation, and mitosis are strongly correlated with a higher RS.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,193.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.