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Cancer Investigation Volume 29, 2011 - Issue 1
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ORIGINAL ARTICLE: CLINICAL TRANSLATIONAL THERAPEUTICS

Response, Survival, and Prognostic Factors After Hepatic Arterial Chemoembolization in Patients With Liver Metastases From Cutaneous Melanoma

Judy AhrarDepartments of Diagnostic Radiology, Biostatistics, and Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
,
Sanjay GuptaDepartments of Diagnostic Radiology, Biostatistics, and Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USACorrespondence[email protected]
,
Joe EnsorDepartments of Diagnostic Radiology, Biostatistics, and Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
,
Kamran AhrarDepartments of Diagnostic Radiology, Biostatistics, and Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
,
David C. MadoffDepartments of Diagnostic Radiology, Biostatistics, and Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
,
Michael J. WallaceDepartments of Diagnostic Radiology, Biostatistics, and Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
,
Ravi MurthyDepartments of Diagnostic Radiology, Biostatistics, and Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
,
Alda TamDepartments of Diagnostic Radiology, Biostatistics, and Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
,
Patrick HwuDepartments of Diagnostic Radiology, Biostatistics, and Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
&
Agop Y. BedikianDepartments of Diagnostic Radiology, Biostatistics, and Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
 show all
Pages 49-55 | Published online: 17 Dec 2010
 
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Abstract

We reviewed the medical records of 42 patients with cutaneous melanoma metastatic to the liver who underwent hepatic artery chemoembolization (HACE) at our institution. HACE resulted in radiologic response (38.9%) or disease stabilization (47.2%) in most patients. The median overall survival (OS) and time to progression (TTP) of liver disease were 7.7 and 6 months, respectively. Patient's age, lactate dehydrogenase (LDH) levels, type of treatment, number of extrahepatic metastatic sites, and response to therapy were found to be significant predictors of OS after HACE. Prolonged survival was seen in patients who responded to HACE (p = .034).

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