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Cancer Investigation Volume 29, 2011 - Issue 1
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ORIGINAL ARTICLE: CLINICAL TRANSLATIONAL THERAPEUTICS

Thrombin Expression in Prostate: A Novel Finding

Manish KohliDepartment of Oncology, Mayo Clinic, Rochester, Minnesota, USA, Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, USA, Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA, Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA, Department of Urology, SUNY Upstate Medical University, Syracuse, New York, USA and Department of Urology & Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USACorrespondence[email protected]
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Karin WilliamsDepartment of Oncology, Mayo Clinic, Rochester, Minnesota, USA, Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, USA, Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA, Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA, Department of Urology, SUNY Upstate Medical University, Syracuse, New York, USA and Department of Urology & Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA
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Jorge L. YaoDepartment of Oncology, Mayo Clinic, Rochester, Minnesota, USA, Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, USA, Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA, Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA, Department of Urology, SUNY Upstate Medical University, Syracuse, New York, USA and Department of Urology & Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA
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Richard A. DennisDepartment of Oncology, Mayo Clinic, Rochester, Minnesota, USA, Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, USA, Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA, Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA, Department of Urology, SUNY Upstate Medical University, Syracuse, New York, USA and Department of Urology & Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA
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Jiaoti HuangDepartment of Oncology, Mayo Clinic, Rochester, Minnesota, USA, Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, USA, Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA, Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA, Department of Urology, SUNY Upstate Medical University, Syracuse, New York, USA and Department of Urology & Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA
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Jay ReederDepartment of Oncology, Mayo Clinic, Rochester, Minnesota, USA, Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, USA, Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA, Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA, Department of Urology, SUNY Upstate Medical University, Syracuse, New York, USA and Department of Urology & Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA
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William A. RickeDepartment of Oncology, Mayo Clinic, Rochester, Minnesota, USA, Department of Environmental Health, University of Cincinnati, Cincinnati, Ohio, USA, Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA, Central Arkansas Veterans Healthcare System, Little Rock, Arkansas, USA, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA, Department of Urology, SUNY Upstate Medical University, Syracuse, New York, USA and Department of Urology & Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA
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Pages 62-67 | Published online: 17 Dec 2010
 
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Abstract

Introduction: A variable repertoire of coagulation protein expression is observed in different cancers. We evaluated expression of thrombin in prostate tissue. Methods: Detection of thrombin was performed using quantitative real-time PCR in fresh tissue and in situ hybridization (ISH) in archival prostate tissue and by immunohistochemistry of prostate tissue microarrays. Results: (Pro)thrombin mRNA expression was detected in cancer tissue and localized to prostatic epithelium and stroma by ISH. Thrombin protein was detected in stroma of benign and malignant epithelium (p <.05). Conclusions: Prostate tissue is a rich reservoir of thrombin. This may have potential for developing antithrombin-based cancer therapy.

ACKNOWLEDGMENTS

The study was supported by Departmental funds from Medicine and Urology, University of Rochester, NCI grant no. CA091956 (Prostate SPORE Awarded to Mayo Clinic), and Funding source, CA123199 (WAR).

The authors are grateful to Professor Charles Francis, MD, Director, Coagulation Lab, University of Rochester, NY, for editorial comments and suggestion with manuscript preparation.

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