Expression of the Forkhead Transcription Factor FOXP1 is Associated with Tumor Grade and Ki67 Expression in Clear Cell Renal Cell Carcinoma

Abstract

Expression of FOXP1 and Ki67 was immunohistochemically assessed on tissue microarrays of 129 cases of clear cell renal cell carcinomas. Overall and disease-specific survival correlated inversely with pT-category, grading and lymph node metastasis in (p < .05). Expression of FOXP1 correlated negatively with tumor grading (p = .02), but neither with pT-category nor with lymph node metastasis. Significant positive correlation was shown for Ki67 expression and tumor stage and lymph node metastasis (p < .05). The overall survival and the disease-specific survival correlated negatively with the Ki67 status (p < .05). FOXP1 expression negatively correlated with Ki67 expression in clear cell renal cell carcinomas (p = .036).

Keywords: :

• Clear cell renal cell carcinoma
• FOXP1
• Ki67
• Survival
• Tumor grading

ACKNOWLEDGEMENTS

This study was supported by MedDrive program of Technical University of Dresden (No. 60.207). The authors thank I. von Bahr for help to ascertain the survival data and Dr. M. Muders for attentively reading the manuscript.