Dynamic Change of Tetraspanin CD151 Membrane Protein Expression in Colorectal Cancer Patients

Abstract

Purpose: To measure the CD151 expression in colorectal cancer (CRC). Methods: CD151 expression was assessed in 179 CRC patients and 39 patients with hepatic liver metastasis. Results: High CD151 expression was observed in 48% of patients with early-stage CRC versus only 33% of patients with metastatic colon cancer. A higher level of tumor invasion status correlated with a decrease in CD151 expression. Metastatic stage and advanced tumor stage correlated with a decreased CD151 expression. Twenty-seven out of the 39-paired samples had high CD151 expression in liver metastasis sites. Conclusions: CD151 expression is decreased in patients with metastatic CRC.

Keywords: :

• CD151
• Colorectal cancer
• Hypoxia
• Tetraspanin family

ACKNOWLEDGMENTS

This project was supported by grants of the National Cheng Kung University Medical Institute and Hospital, Tainan, Taiwan.