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Cancer Investigation Volume 30, 2012 - Issue 9
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CELLULAR AND MOLECULAR BIOLOGY

Immune Protection Function of Multipotent Mesenchymal Stromal Cells: Role of Transforming Growth Factor-β1

Zhi-Gang ZhaoDepartment of Hematology and Oncology, the Oncology Hospital of Tianjin Medical University, Tianjin, P.R. China,Correspondence[email protected]
,
Zeng CaoInstitute of Hematology and Blood Diseases Hospital, State Key Lab of Experimental Method of Hematology, Chinese Academy of Medical Sciences and Peking Union of Medical College, Tianjin, P.R. China,
,
Wen XuDepartment of Hematology and Oncology, the Oncology Hospital of Tianjin Medical University, Tianjin, P.R. China,
,
Li SunDepartment of Hematology, Institute of Hematology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, P.R. China
,
Yong YouDepartment of Hematology, Institute of Hematology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, P.R. China
,
Fang LiDepartment of Hematology and Oncology, the Oncology Hospital of Tianjin Medical University, Tianjin, P.R. China,
,
Qiu-Bai LiDepartment of Hematology, Institute of Hematology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, P.R. China
&
Ping ZouDepartment of Hematology, Institute of Hematology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, P.R. China
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Pages 646-656 | Published online: 28 Sep 2012
 
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Abstract

The immunosuppressive functions of multipotent mesenchymal stromal cells (MSCs) may give cancer cells a survival advantage. This study tests the hypothesis that MSCs protect leukemia cells from immune clearance. Our results demonstrate that MSCs are capable of inhibiting peripheral blood mononuclear cells (PBMNCs) proliferation and their migration toward leukemic cells by the reduction of CCL5 and CXCL12. In addition, we find that MSCs can inhibit the cytolytic functions of NK-cells and CTLs. TGF-β1 secreted by MSCs is responsible for impaired CTLs and NK function by down-modulating surface NKG2D expression. These inhibitory functions of MSCs have negative effects on the CTLs or NK-mediated graft-versus-leukemia (GVL), particularly in the allogeneic hematopoietic stem cells transplantation setting.

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