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Cancer Investigation Volume 31, 2013 - Issue 2
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CLINICAL TRANSLATIONAL RESEARCH

CFL1 and Arp3 are Biomarkers for Metastasis and Poor Prognosis of Squamous Cell/Adenosquamous Carcinomas and Adenocarcinomas of Gallbladder

Zhu-Lin YangResearch Laboratory of Hepatobiliary Diseases, Second Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China,
,
Xiongying MiaoResearch Laboratory of Hepatobiliary Diseases, Second Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China,Correspondence[email protected]
,
Li XiongResearch Laboratory of Hepatobiliary Diseases, Second Xiangya Hospital, Central South University, Changsha, Hunan, P. R. China,
,
Qiong ZouDepartment of Pathology, Third Xiangya Hospital,
,
Yuan YuanDepartment of Pathology, Third Xiangya Hospital,
,
Jinghe LiDepartment of Pathology, Basic School of Medicine,
,
Lufeng LiangDepartment of Hepatobiliary and Pancreatic Surgery, Hunan Provincial People's Hospital, Changsha, Hunan, P. R. China,
,
Meigui ChenDepartment of Pathology, Loudi Central Hospital, Loudi, Hunan, P. R. China,
&
Senlin ChenDepartment of Pathology, Hunan Provincial Tumor Hospital, Changsha, Hunan, P. R. China
 show all
Pages 132-139 | Published online: 15 Jan 2013
 
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Abstract

Cofilin-1 (CFL1) and Arp3 expression in 46 squamous cell and adenosquamous carcinomas (SC/ASCs) and 80 adenocarcinomas (ACs) were measured by using immunohistochemistry. Positive CFL1 and Arp3 expression were significantly associated with large tumor size, high TNM stage, lymph node metastasis, and decreased overall survival in both SC/ASC and AC patients (p < .001). Multivariate Cox regression analysis showed that positive CFL1 and Arp3 expression are independent poor-prognostic factors for both SC/ASC and AC patients. Our study suggested that positive CFL1 and Arp3 expression are closely related to tumor progression, metastasis, and poor prognosis of gallbladder cancer.

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