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Cancer Investigation Volume 31, 2013 - Issue 7
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ORIGINAL ARTICLE

Ovarian Cyst Fluids Are a Cache of Tumor Biomarkers That Include Calgranulin A and Calgranulin B Isoforms

Hollie S. SkaggsMylan Pharmaceuticals Inc., Morgantown, West Virginia, USA,
,
Brook A. SaundersKnoxville Gynecologic Cancer Specialists, Knoxville, Tennessee, USA,
,
Rachel W. MillerDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Kentucky, Lucille P. Markey Cancer Center, Lexington, Kentucky, USA,
,
Scott T. GoodrichDivision of Gynecologic Oncology, Madigan Army Medical Center, United States Army Medical Command, Tacoma, Washington, USA,
,
Monica S. KingRegistrat-Mapi, Clinical Research Organization, Lexington, Kentucky, USA,
,
Kimberly D. KimblerKentucky Cancer Registry, University of Kentucky, Lexington, Kentucky, USA,
,
Adam J. BranscumBiostatistics Program, Oregon State University, College of Public Health and Human Sciences, Corvallis, Oregon, USA,
,
Eric T. FungVermillion, Inc., Austin, Texas, USA,
,
Paul D. DePriestDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Kentucky, Lucille P. Markey Cancer Center, Lexington, Kentucky, USA,
,
John R. van NagellDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Kentucky, Lucille P. Markey Cancer Center, Lexington, Kentucky, USA,
,
Frederick R. UelandDepartment of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Kentucky, Lucille P. Markey Cancer Center, Lexington, Kentucky, USA,
&
Andre T. BaronCorrespondence[email protected]
 show all
Pages 433-453 | Received 30 Jun 2012, Accepted 24 Apr 2013, Published online: 05 Aug 2013
 
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Abstract

SELDI-TOF MS analysis of cyst fluids identified 95 peaks that discriminate malignant, borderline, and benign ovarian tumors. Three prominent peaks, which correspond to calgranulin A (m/z 10847) and two isoforms of calgranulin B (m/z 12717 and 13294), have higher concentrations in borderline and malignant cyst fluids. Together, calgranulin A and B distinguish borderline and malignant tumors from benign tumors with 28.6% and 63.6% sensitivity for early stage disease, respectively, at 95% specificity and with 74.8% accuracy. Ovarian cyst fluids are useful for discovering discriminatory biomarkers, such as calgranulin, which may have utility for detecting, diagnosing, and biochemically classifying ovarian tumors.

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