The Role of p53 Protein and MMP-2 Tumor/Stromal Cells Expression on Progressive Growth of Ovarian Neoplasms

Abstract

The aim of our study was to evaluate p53 gene/protein status and MMP-2 expression in respect to ovarian tumors progress to define the role of these markers in the metastasis of ovarian carcinomas. MMP-2 and p53 alterations were evaluated on 80 malignant, 30 benign ovarian tumors, and 62 metastatic lesions by using HRM method for mutations in p53 gene and by using RT-PCR for mRNA MMP-2 level. Our data indicate that parallel expression of MMP-2 epithelial/stromal cells and p53 may enhance cells invasion and metastasis in ovarian carcinoma.

Keywords: :

• Ovarian cancer
• Immunology/immunobiology
• Invasion & metastasis
• Molecular biology