Migration of Transformed Bone Marrow-Derived Cells with Peripheral Neural Tumor Traits In Vivo

Abstract

The identification of the original cells in tumors may allow for measures that protect the original cells and prevent tumor formation. In the present study, we isolated a subpopulation of cells with the features of neural tumor cells from transformed BMDCs in vitro. These neural tumor cells expressed the markers of neural tumor progenitor cells and differentiated neural tumor cells in vitro. Moreover, the subcloned cells from transformed BMDCs could migrate to distant tissues and drive peripheral neural tumors in vivo. Therefore, our results further verify that transformed mouse BMDCs are a potential source of peripheral neural tumors.

Keywords::

• Bone marrow-derived cells (BMDCs)
• Transformation
• Peripheral neural tumors
• Source of tumor
• Neural tumor progenitor cells
• Migration