Association Between Interleukin-8 –251A/T Polymorphism and Risk of Lung Cancer: A Meta-Analysis

Abstract

This study is to evaluate the association between IL-8 –251A/T polymorphism and lung cancer risk in diverse populations. We performed a meta-analysis of six case-control studies that included 3,265 lung-cancer cases and 3,607 case-free controls. Overall, results showed that the IL-8 –251A/T polymorphism was not associated with a significantly increased risk of lung cancer in all genetic models. However, stratified by ethnicity, a significantly increased risk was found among Asians. In conclusion, IL-8 –251A/T polymorphism is associated with lung cancer susceptibility in Asians and the –251 A allele may increase risk of lung cancer in Asians.

Keywords: :

• Lung cancer
• Interleukin-8
• Polymorphism
• Meta-analysis