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Cancer Investigation Volume 33, 2015 - Issue 7
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Original Article

Downregulation of HOXC6 in Serous Ovarian Cancer

David L. TaitCarolinas Medical Center, Levine Cancer Institute, Division of Gynecologic Oncology, Charlotte, North Carolina, USA,
,
Zahra Bahrani-MostafaviUNC-Charlotte, College of Computing and Informatics, Charlotte, North Carolina, USA,
,
C. Greer VestalUNC-Charlotte, Department of Biological Sciences, Charlotte, North Carolina, USA
,
Christine RichardsonUNC-Charlotte, Department of Biological Sciences, Charlotte, North Carolina, USA
&
M. Taghi MostafaviUNC-Charlotte, College of Computing and Informatics, Charlotte, North Carolina, USA,Correspondence[email protected]
Pages 303-311 | Received 27 Nov 2013, Accepted 08 Apr 2015, Published online: 05 Jun 2015
 
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Abstract

Homeobox (HOX) genes encode transcription factors critical to morphogenesis and cell differentiation. Although dysregulation of several HOX genes in ovarian cancer has been reported, little is known about HOXC6 expression in epithelial ovarian cancer. In this report, analysis of laser capture microdissected samples determined HOXC6 expression patterns in normal versus malignant serous ovarian carcinoma tissues. HOXC6 protein was quantified by ELISA in parallel serum samples and further validated in a larger cohort of serum samples collected from women with and without serous ovarian carcinoma. These data demonstrate significant downregulation of HOXC6 in serous ovarian cancer.

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