Focal Adhesion Proteins α- and β-Parvin are Overexpressed in Human Colorectal Cancer and Correlate with Tumor Progression

Abstract

This study aims to address the role of focal adhesion proteins α- and β-parvin in human colorectal carcinoma (CRC). Expression of α- and β-parvin was examined by immunohisto- chemistry and real-time RT-PCR in a series of human CRC. Parvins were overexpressed in CRC and their expression correlated significantly with tumor invasion, lymph node metastasis, and disease stage. A significant positive correlation of parvins protein expression with overexpression of integrin-linked kinase, p-AKT, and nuclear β-catenin, as well as with downregulation of E-cadherin was also observed. In conclusion, overexpression of α- and β-parvin seems to be implicated in human colorectal cancer progression.

Keywords::

• Alpha-parvin
• Beta-parvin
• Colorectal cancer
• EMT
• Focal adhesions
• Integrin-linked kinase
• Tumor progression

ACKNOWLEDGMENTS

We thank Dr Maria Repanti for kindly providing FFPE tissue samples.

DECLARATION OF INTEREST

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper article.

The present work was funded by EOGE—Oncology Research Fund, Greece.