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Cancer Investigation Volume 33, 2015 - Issue 9
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ORIGINAL ARTICLE

Claudin 1 Promotes Migration and Increases Sensitivity to Tamoxifen and Anticancer Drugs in Luminal-like Human Breast Cancer Cells MCF7

Bowen ZhouFaculty of Health Sciences, Department of Pathology, College of Medicine, University of Manitoba, Winnipeg, Canada
,
Anne BlanchardFaculty of Health Sciences, Department of Pathology, College of Medicine, University of Manitoba, Winnipeg, Canada;Faculty of Health Sciences, Department of Physiology and Pathophysiology, College of Medicine, University of Manitoba, Winnipeg, Canada
,
Nan WangFaculty of Health Sciences, Department of Physiology and Pathophysiology, College of Medicine, University of Manitoba, Winnipeg, Canada
,
Xiuli MaFaculty of Health Sciences, Department of Pathology, College of Medicine, University of Manitoba, Winnipeg, Canada
,
Jihyun HanFaculty of Health Sciences, Department of Pathology, College of Medicine, University of Manitoba, Winnipeg, Canada
,
Ingo SchroedterFaculty of Health Sciences, Department of Pathology, College of Medicine, University of Manitoba, Winnipeg, Canada
,
Etienne LeygueFaculty of Health Sciences, Department of Biochemistry and Human Genetics, College of Medicine, University of Manitoba, Winnipeg, Canada
&
Yvonne MyalFaculty of Health Sciences, Department of Pathology, College of Medicine, University of Manitoba, Winnipeg, Canada;Faculty of Health Sciences, Department of Physiology and Pathophysiology, College of Medicine, University of Manitoba, Winnipeg, CanadaCorrespondence[email protected]
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Pages 429-439 | Received 15 Dec 2014, Accepted 08 Jun 2015, Published online: 17 Aug 2015
 
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Abstract

Downregulation of claudin 1, a critical tight junction protein, has been correlated with increased invasiveness in breast cancer. However, recent studies suggest that claudin 1 contributes to the progression of some molecular subtypes of breast cancer. In this study, claudin 1 promotes migration in luminal-like MCF7 human breast cancer cells and increases their sensitivity to tamoxifen, etoposide, and cisplatin. We also observed an inverse relationship between upregulation of claudin 1 and TGFβ. Collectively, our results suggest that claudin 1 has the potential to be used as a predictive marker for treatment efficacy for specific breast cancer patient subgroups.

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