Critical analysis of protein signaling networks involved in the regulation of plant secondary metabolism: focus on anthocyanins

Abstract

Anthocyanin biosynthesis in Arabidopsis is a convenient and relatively simple model for investigating the basic principles of secondary metabolism regulation. In recent years, many publications have described links between anthocyanin biosynthesis and general defense reactions in plants as well as photomorphogenesis and hormonal signaling. These relationships are complex, and they cannot be understood intuitively. Upon observing the lacuna in the Arabidopsis interactome (an interaction map of the factors involved in the regulation of Arabidopsis secondary metabolism is not available), we attempted to connect various cellular processes that affect anthocyanin biosynthesis. In this review, we revealed the main signaling protein modules that regulate anthocyanin biosynthesis. To our knowledge, this is the first reconstruction of a network of proteins involved in plant secondary metabolism.

• Anthocyanins
• Arabidopsis thaliana
• interactome
• protein networks
• secondary metabolism

Declaration of interest

This work was supported by a grant from the Russian Science Foundation (grant number 14–14-00230).

Supplementary material available online Supplementary Figures 1-7