Walmor C. DeMello & Edward D. Frohlich, editors. Renin angiotensin system and cardiovascular disease. Humana Press, Totowa, New Jersey. ISSN 1-60761-185-6, ISBN 978-1-60761-185-1.
The renin–angiotensin system (RAS) plays an essential role in cardiac and vascular functions and their connection in the generation of cardiovascular diseases. The book Renin angiotensin system and cardiovascular disease covers important aspects such as intracellular signaling, regulation of cell volume in the failing heart, the presence of an intracrine RAS, and the influence of prorenin/renin, angiotensin II, angiotensin (1–7) and aldosterone. Furthermore, the role of the mineralocorticoid receptor as an imperative component of the intracrine RAS and as a regulator of extracellular action of angiotensin II is described, addressing the view that aldosterone inhibitors are useful in the treatment of heart failure and hypertension. Renin angiotensin system and cardiovascular disease provides readers with a review of major topics involving RAS and cardiovascular disease. The volume editors, Dr Walmor C. DeMello and Dr Edward Frohlich, both established specialists and experts within their respective areas, discuss a range of important topics relating to RAS and pathophysiology of hypertension to inhibiting RAS in patients with heart failure and myocardial infarction.