Regulatory immune cell subsets in autoimmunity

Abstract

The immune system is equipped with different checkpoints that ensure the maintenance of immune tolerance to self-antigens and the prevention of autoimmunity. One mechanism of peripheral tolerance involves the activity of specialized subsets of immune cells that are capable to regulate and/or suppress pro-inflammatory immune responses. These regulatory cells include multiple subsets that belong to both the adaptive and innate immune systems. This issue of Autoimmunity describes the role of the different types of immunoregulatory cells in autoimmune diseases.

Keywords::

• Autoimmunity
• regulatory cells
• immune cells
• cell subsets
• autoimmune disease

Declaration of interest: The author reports no conflicts of interest. The author alone is responsible for the content and writing of the paper.