The effect of MS14 on Th2 cytokines pattern in Balb/C mice

Abstract

The tendency of immune response toward either Th1 or Th2 cytokine pattern can cause a number of pathologic conditions. Multiple sclerosis is postulated to be a Th1-type cell-mediated autoimmune disease. MS14—an Iranian natural product—seems to possess anti-inflammatory properties. Thus, we studied the effect of orally administered MS14 on Th2 cytokines (IL-5 and IL-10) in normal Balb/C mice (100 mg/kg; 5 days). The result indicated that activated splenocytes of MS14 group produced significantly more IL-5 and IL-10 (3–4 times in comparison with control group mice). MS14 could upregulate Th2 cytokine and thereby it may possess immunoregulatory properties probably useful in treatment of some diseases.

Keywords:

• Immunomodulator
• interleukin-5 (IL-5)
• interleukin-10 (IL-10)
• MS14
• TH2 cytokines

Acknowledgement

The authors thank Mr. Davood Jamali for carry out ELISA tests.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.