The effect of simvastatin treatment on bone repair of femoral fracture in animal model

Abstract

The aim of this research was to evaluate the fracture healing area in osteoporotic femur of female rats restrained by stainless steel wire by statin administration in two different doses (5 mg and 20 mg). Ninety female rats were divided into six groups (n = 15): SH, SH-5 mg, SH-20 mg, OVX, OVX-5 mg, and OVX-20 mg. The surgery consisted of the fracture of the left femur bone and stabilization by K-wire and the administration was restricted and weekly controlled in the drinking water. The euthanasia was conducted at three different moments, five animals per period: 7 d, 14 d, and 28 d. Densitometry, zymography, and histological analyses showed a significant difference between some groups. According to these findings, simvastatin promoted a positive action for bone repair, especially in the osteometabolic group treated with 20 mg of the drug.

• Fracture healing
• MMP and ovariectomy
• statins
• simvastatin

Declaration of interest

The authors report that they have no conflicts of interest. The research for this paper was financially supported by the FAPESP Process: number 2011/13449-0, all the authors are gratefully to the FAPESP.