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Abstract
Recurrent Aphthous Stomatitis (RAS) is the most common form of nontraumatic oral mucosal ulceration. Numerous studies have suggested a wide variety of the probable etiologic mechanisms (1). However, various therapeutic approaches that have been made to date are controversial since the etiopathology has not been evidently elucidated yet. Corticosteroids are the most commonly used drugs in the treatment of Aphthous Stomatitis. However, they cause side effects when they are used topically in conventional dosage forms (2-4). In earlier study, we tested the potential usage of liposomes as drug carriers to the ulcerated rat oral mucosa by determining whether liposomes could increase local and decrease systemic concentrations of a corticosteroid, dexamethasone sodium phosphate (DSP). We showed that liposomal encapsulation increased drug concentrations at the desired site of action and decreased concentrations at the internal organs (5).In this study by using the combination of two types of dosage forms i.e. liposome dispersion and adhesive gel (liposome dispersion in gel; Gelosome), the therapeutic effect of DSP liposomes was investigated comparing with control groups. The results were evaluated from clinical point of view and histopathologically. In addition, in vitro release and its fitting to different release models was investigated.