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Abstract
Purpose: To evaluate morphology of the optic nerve head and visual field in AIDS patients without retinitis.
Methods: One randomly selected eye from 246 patients with AIDS without retinitis was evaluated from prospective multicenter Longitudinal Studies of Ocular Complications of AIDS. Stereo fundus photographs of OHN and serial VF data over 5-years were analyzed. Main outcomes included vertical cup-to-disc ratio (CDR), mean deviation, and pattern standard deviation scores on VF testing.
Results: The median CDR was 0.39 at enrollment and 0.40 at 5-year follow-up. An unadjusted linear regression model revealed a mean change in CDR of 0.004 after 5-years (P = 0.04). After adjustment for practice effect, there were no statistically significant changes in VF performance observed during the 5 years of follow-up.
Conclusions: We detected clinically minimal, but statistically significant changes in ONH morphology and no change in VF performance among eyes of patients with AIDS and without retinitis.
Declaration of interest: Publication of this article was supported by Longitudinal Study of the Ocular Complications of AIDS (LSOCA) grant support from the National Eye Institute, Bethesda, Maryland to the Mount Sinai School of Medicine, New York, New York (U10 EY 08052); the Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland (U10 EY 08057); and the University of Wisconsin, Madison, Madison, Wisconsin (U10 EY 08067). Funding entities had no role in the conduction or presentation of this study. Involved in study design (I.K., S.G., J.T., W.R.F.); data collection (S.G., A.A., J.E.T., M.L.V.N., and the SOCA Research Group); data management and analysis (I.K., A.A., S.G., M.L.V.N.); data interpretation (I.K., S.G., A.A., M.L.V.N., J.E.T., W.R.F.); preparation of initial draft of manuscript (all authors); and review and approval of manuscript (all authors, as well as Study Officers of LSOCA, representing the SOCA Research Group, reviewed and approved the manuscript). The SOCA Research Group: LSOCA is registered at www.clinicaltrials.gov (NCT00000168).