Roles of IL-10 in Ocular Inflammations: A Review

Abstract

Introduction: This review represents the current in vitro, in vivo, animal and human investigations on the roles of IL-10 in ocular inflammatory conditions.

Materials and methods: The data sources were literature reviews, including Pub Med, Medline, and ISI databases (since1989 to mid-2012). Search items were, IL-10, chemokines, cytokines, alone or in combination with, serum, aqueous, vitreous eye, ocular, ocular tissues, ophthalmic, and review.

Results: Ocular effects of IL-10 depend on the sources of the secretion and sites of the action. IL-10 plays important anti-inflammatory and especially anti-angiogenic activities in ocular tissues such as the conjunctiva, cornea, retina, choroid, and orbit.

Conclusion: IL-10 plays major anti-inflammatory and anti-angiogenic roles in most of the ocular inflammations. Also, IL-10 plays a role in development of anterior chamber-associated immune deviation (ACAID). Any manipulation of IL-10 for treatment purposes should be considered very cautiously due to its potential hazards to the immune system.

KEYWORDS::

• Angiogenesis
• Chemokine
• Cytokine
• IL-10
• Ocular inflammations
• Review

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.