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Ocular Immunology and Inflammation Volume 22, 2014 - Issue 1
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Research Article

Lacrimal Gland Uptake of 67Ga-gallium Citrate Correlates with Biopsy Results in Patients with Suspected Sarcoidosis

Bradford L. TannenDepartment of Ophthalmology, Mount Sinai School of Medicine New York, New YorkUSA
, MD, JD,
Anton M. KolomeyerInstitute of Ophthalmology and Visual Science
, MD, PhD,
Roger E. TurbinInstitute of Ophthalmology and Visual Science
, MD,
Larry FrohmanInstitute of Ophthalmology and Visual Science;Department of Neurology & Neurosciences, University of Medicine and Dentistry of New Jersey Newark, New JerseyUSA
, MD,
Paul D. LangerInstitute of Ophthalmology and Visual Science
, MD,
Cheongeun OhDepartment of Population Health, New York University New York, New YorkUSA
, PhD,
Nasrin V. GhesaniDepartment of Radiology, University of Medicine and Dentistry of New Jersey Newark, New JerseyUSA
, MD,
Lionel S. ZuckierDepartment of Medicine University of Ottawa, OttawaCanada
, MD &
David S. ChuInstitute of Ophthalmology and Visual Science;Metropolitan Eye Research and Surgery Institute, Palisades Park New JerseyUSACorrespondence[email protected]
, MD show all
Pages 15-22 | Received 18 Sep 2012, Accepted 21 Mar 2013, Published online: 03 Jun 2013
 
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Abstract

Purpose: To investigate whether lacrimal gland uptake on 67Ga-gallium citrate scintigraphy correlates with histopathologic evidence of sarcoidosis.

Methods: A retrospective, pilot study of 31 patients with suspected sarcoidosis who underwent gallium scintigraphy and lacrimal gland biopsy. Lacrimal gland gallium uptake was assessed by subjective visual scoring (SVS) and lacrimal uptake ratio (LUR).

Results: Eleven (36%) patients had lacrimal gland biopsies containing noncaseating granulomas. A statistically significant correlation was found between lacrimal gland gallium uptake and biopsy positivity using SVS (p = 0.03) or LUR (p = 0.01). Using SVS, biopsy positivity rate increased from 0 to 50% in patients with mild to intense uptake. Using LUR, biopsy positivity rate increased linearly as the ratio increased from 13% (LUR < 4) to 100% (LUR > 8).

Conclusions: Lacrimal biopsy positivity rate significantly correlated with gallium uptake on scintigraphy. Both SVS and LUR methods appear to correlate with histologic results and may potentially aid in patient selection for biopsy.

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