Changes in Scleral Architecture in Chronic Vogt–Koyanagi–Harada Disease

ABSTRACT

Purpose: To describe scleral changes in chronic VKH.

Methods: Medical records of patients with chronic VKH were retrospectively reviewed. Change of scleral architecture was defined as progressive posterior bowing on OCT, axial length elongation, and/or increased myopia more than –1.0 D, not explicable by other etiologies.

Results: In total, 28 eyes (16 patients) with mean age of disease onset 32.5 ± 14.0 years were included in the study. Disease duration was 15.1 ± 10.2 years. Eight eyes (28.6%) showed progressive scleral architectural changes. Five eyes (18%) developed scleral changes on OCT, not seen on prior imaging (2–12 years earlier). One eye had posterior bowing on OCT with increased axial length, both eyes of a bilateral pseudophake developed increased myopia with increased axial length. Well-circumscribed chorioretinal atrophy within the arcade was associated with progressive scleral change.

Conclusions: Progressive scleral change may develop as a late complication of VKH. The association with well-circumscribed chorioretinal atrophy suggests that chronic choroidal inflammation may be responsible.

Keywords:

• VKH
• OCT
• choroid
• uveitis
• sclera

This article refers to:

Choroidal Thinning May Change Scleral Architecture

This article is referred to by:

Response to Kaya and Yildirim’s Letter: “Choroidal Thinning May Change Scleral Architecture”

DECLARATION OF INTEREST

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.