Clinical Features of Systemic Metastatic Retinal Lymphoma in Japanese Patients

ABSTRACT

Purpose: Systemic metastatic retinal lymphoma (SMRL) originates in systemic organs. It has been reported to exhibit clinical features similar to those of primary vitreoretinal lymphoma (PVRL). We report six cases of SMRL in a single-center survey in Japan.

Methods: The clinical and pathologic features in SMRL at the Kyushu University Hospital were retrospectively studied.

Results: The mean patient age at the onset of ocular involvement was 75.3 years. Four patients had brain involvement. The primary sites were: breast (2); chest (1); testis (1); intestinal tract (1); and nasal sinus (1). In all patients, the cytology of vitreous samples indicated diffuse large B-cell lymphoma (DLBCL).

Conclusions: DLBCL is the most common subtype in our study. The prevalence of CNS involvement in patients with SMRL is similar to that with PVRL. The testis and breast may be common sites of origin for SMRL.

Keywords:

• Clinical features
• CNS involvement
• primary organs
• single-center study
• vitreoretinal lymphoma

DECLARATION OF INTEREST

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Funding

This work supported by a grant from JSPS KAKENHI Grant Number 15K10896 [grants C (A.T.)] from the Ministry of Education, Science, Sports and Culture, Japan.

Additional information

Funding

This work supported by a grant from JSPS KAKENHI Grant Number 15K10896 [grants C (A.T.)] from the Ministry of Education, Science, Sports and Culture, Japan.