25-Hydroxyvitamin D levels are related to hyperinsulinemia in polycystic ovary syndrome

Abstract

Aim: To determine 25-hydroxyvitamin D levels and the relationship between 25-hydroxyvitamin D and metabolic disturbances including insulin resistance in women with PCOS.

Materials and methods: We compared biochemical, hormonal parameters and 25-hydroxyvitamin D levels of 58 women with PCOS and 38 body mass index matched controls.

Results: There was no difference in 25-hydroxyvitamin D levels of women with PCOS and the control group. Low 25-hydroxyvitamin D levels in women with PCOS were related to higher insulin levels (r = − 0.271 and p = 0.042). More than 90% of the subjects had hypovitaminosis D. The negative relationship between 25-hydroxyvitamin D levels and body mass index did not reach statistical significance.

Conclusion: Low 25-hydroxyvitamin D levels were related to hyperinsulinemia in women with PCOS.

Chinese abstract

目的：本研究旨在研究多囊卵巢综合征女性25-羟维生素D水平，以及25-羟维生素D与代谢紊乱，包括胰岛素抵抗之间的关系。

材料与方法：我们比较58名多囊卵巢综合征及38名身体指数匹配的对照组女性的生物化学，激素指标，以及25-羟维生素D的水平。

结果：PCOS组与对照组间25-羟维生素D水平没有明显差异。PCOS组女性中25羟维生素D水平低者，其胰岛素水平较高（r=-0.217,p=0.042）。超过90%的受试者有维生素D缺乏症。但25-羟维生素D以及体重指数之间的负相关性并没有达到明显的统计学差异。

结论：PCOS患者低25-羟维生素D水平与高胰岛素水平相关。

• Insulin resistance
• obesity
• polycystic ovary syndrome
• vitamin D