Adding serum estradiol measurements to ultrasound monitoring does not change the yield of mature oocytes in IVF/ICSI

Abstract

In a non-randomized, comparative prospective study (416 patients) we compared the outcome of IVF/ICSI in two parallel control groups: one in which patients were followed up using combined monitoring (ultrasound plus serum estradiol monitoring, the UHM group) and one in which only ultrasound monitoring was used (the UM group). This study has taken the number of mature oocytes at the moment of egg retrieval as its primary end variable. After adjustment for age, gravidity, antagonist protocol, AMH and infertility diagnosis, the average difference in number of mature oocytes between the UHM group and the UM group was −0.4 (95% CI: −1.7 to 1.0), which met our definition of clinical equivalence (95% CI for the adjusted mean difference between −2 and 2). Larger studies are still needed to evaluate the differences in the live birth rates per cycle and to further confirm that blood sampling definitively has no added value in monitoring ovarian stimulation for IVF/ICSI.

Chinese abstract

我们在一项非随机、对照、前瞻性研究中（416例患者）比较了IVF/ICSI中两个平行对照组的结果：一组患者应用超声联合血雌二醇进行监测（ultrasound plus serum estradiol monitoring，UHM），一组患者仅应用超声监测（ultrasound monitoring，UM）。本研究以取卵时成熟卵母细胞的数量为主要研究终点。在对年龄、孕次、拮抗剂方案、AMH水平、不孕症诊断进行校正后，UHM组和UM组的成熟卵母细胞数量的平均差异是-0.4（(95% CI： -1.7- 1.0），这与临床等效的定义相符（调整后的平均差的95% CI介于-2到2之间）。仍需要更大型的研究来评估周期活产率及进一步确定IVF/ICSI中采血检测对卵巢刺激监测的最终结果无附加价值。

• Estradiol
• IVF
• mature oocyte
• monitoring
• ultrasound