High DHEAS/free testosterone ratio is related to better metabolic parameters in women with PCOS

Abstract

Aims: To demonstrate the effects of DHEAS/free testosterone (DHEAS/FT) ratio on metabolic parameters in women with and without polycystic ovary syndrome (PCOS).

Methods: The data of 91 women with PCOS and 66 women in the control group were collected retrospectively.

Results: DHEAS/FT of the control group was higher than that of PCOS group (684.93 ± 300.54 to 517.2 ± 300.8, p < 0.001). DHEAS/FT correlated with BMI (r = −0.352, p = 0.001), WHR (r = −0.371, p = 0.0219), LDL (r = −0.227, p = 0.031), HOMA-IR (r = −0.36, p = 0.001) and FAI (r = −0.639, p = 0.001) negatively and with HDL (r = 0.344, p = 0.001) and SHBG (r = 0.646, p = 0.001) positively. In the control group, DHEAS/FT correlated with BMI (r = −0.334, p = 0.007), CRP (r = −0.297, p = 0.016) and FAI (r = −0.399, p = 0.01) negatively.

Conclusions: High DHEAS/FT ratios are related to a better metabolic phenotype in women with PCOS and low levels can be used to detect women with PCOS that have a higher risk of metabolic problems.

• DHEAS
• free testosterone
• metabolism
• polycystic ovary syndrome

Declaration of interest

The authors have no conflicts of interest to declare.