Abstract
We investigated the association between the amount and duration of smoking on biochemical, clinical parameters and the ovarian morphology in women with polycystic ovary syndrome (PCOS). That was a retrospective study. These women were divided into two groups, non-smokers (217) and smokers (92). The amount of cigarettes and duration of smoking was measured in pack-years. Both groups underwent clinical evaluation, biochemical and hormone analysis, transvaginal ultrasound and oral glucose tolerance tests (OGTT). The mean value of the number of cigarettes was 14.8 (±8.8) and the median value of pack-years in the smokers group was 4.0 (1.5–7.5). Smokers group has significantly higher free testosterone (F-T), 17-hydroxyprogesterone (17-OHP), delta 4 androstenedione (Δ4-A), T4, low-density lipoprotein (LDL), and white blood cells (WBC). During correlation of all the above parameters and pack-years, there has been significant positive correlation in F-T and Δ4-A. The participants with more pack-years showed statistically higher values of F-T and Δ4-A. There was also a significant positive correlation between total cholesterol, triglycerides, WBC and pack-years of the participants. Prolactin (PRL) has been inversely associated with pack-years. We concluded that the increase of pack-years aggravated lipid profile, WBC and decreased PRL levels, in PCOS patients.
Chinese abstract
我们研究了吸烟的数量和持续时间与多囊卵巢综合征女性的生化和临床参数,以及卵巢形态之间的关系。此研究为回顾性研究,这些多囊卵巢综合征女性被分为两组,不吸烟组(217)和吸烟组(92)。吸烟的数量和持续时间通过每年吸烟的包数来判断。对两组进行临床评估、生化和性激素分析、阴道超声和口服葡糖糖耐量试验。香烟数量的平均数是14.8(±8.8),吸烟组每年吸烟包数的中位数是4.0(1.5-7.5)。吸烟组的游离睾酮、17羟孕酮和D4-雄烯二酮、T4、低密度脂蛋白和白细胞数明显比不吸烟组高。对比上述所有参数和年吸烟包数,发现游离睾酮与D4-雄烯二酮显著正相关。年吸烟包数多的参与者的游离睾酮 和D4-雄烯二酮的明显较高。参与者的总胆固醇、甘油三酯和白细胞数与其年吸烟包数之间也有明显的正相关。泌乳素和年吸烟包数呈负相关。我们得出结论,多囊卵巢综合征患者年吸烟包数的增加使得她们的血脂和白细胞数增加了,并且降低了她们的泌乳素水平。
Declaration of interest
Authors do not have any conflicts of interest.