Pregnancy after oocyte donation in 45, X Turner syndrome women, complicated by gestational diabetes and polyhydramnios. Case report and mini-review of literature

Abstract

Patients suffering from Turner syndrome (TS) demonstrate characteristic clinical features, with a short stature and gonadal dysgenesis causing infertility in most patients. Spontaneous pregnancies in women with TS are quite rare and pregnancy outcomes involving an increased risk of miscarriage and stillbirths are observed. In this case report, we present a 28 years old pregnant woman with the diagnosis of TS. Due to hypergonadotrophic hypogonadism, she was proposed an in vitro fertilization (IVF) program with an oocyte donor from unrelated anonymous women. After the second transfer, implantation occurred. In the 24th week of gestation, gestational diabetes class 1 was diagnosed. In the 31st week of gestation, polyhydramnios was diagnosed, although other parameters were reassuring. Considering the polyhydramnios, along with the diagnosis of Turner syndrome in the mother, we decided to perform an elective cesarean section. Subsequently, a healthy term male was born. For most women with the diagnosis of TS, the only way to become pregnant is through oocyte donation. The aim of this work was to characterize the course of pregnancy in TS patient and review literature addressing this issue.

Chinese abstract

特纳综合征(TS)患者具有典型临床特征, 表现为身材矮小和性腺发育不良导致大多数患者不孕。TS妇女自然妊娠极为罕见, 妊娠结局包括流产和死产的风险高。本个案报道为一名28岁诊断TS的妊娠妇女。由于促性腺激素过多导致性腺功能低下, 建议患者行IVF, 卵子捐赠来源于不相关匿名妇女。第二次移植后妊娠成功。孕24周诊断1型妊娠期糖尿病。孕31周诊断羊水过多, 其他指标尚可。考虑羊水过多和母亲患特纳综合征, 我们决定实施剖宫产术。随后, 诞生一名健康男婴。对于大多数诊断TS的妇女, 妊娠的唯一方法为卵子捐赠。该文的目的是展示TS患者的妊娠过程及相关文献综述。

• Oocyte donation
• pregnancy
• Turner syndrome

Declaration of interest

The authors report that they have no conflicts of interest.