The prevalence of Gly972Arg and C825T polymorphisms in Slovak women with polycystic ovary syndrome and their relation to the metabolic syndrome

Abstract

Aim. To assess the prevalence of IRS-1 Gly972Arg and GNB3 C825T polymorphisms in women with polycystic ovary syndrome (PCOS) and their relation to the metabolic syndrome and hyperandrogenaemia.

Methods. Fifty-three female patients with diagnosis of PCOS and 21 healthy women were genotyped for the commom Gly972Arg and C825T polymorphisms. Body mass index, serum glucose, insulin, insulin sensitivity index HOMA (homeostasis model assessment) and serum lipoproteins were estimated.

Results. The prevalence of Gly972Arg genotype in PCOS women was 22.64% and was not significantly higher than in control group with the prevalence 9.52%. The frequency of T alleles was 28% in PCOS group that was similar to control group (29%). We did not find the significant differences in the frequency of TC + TT genotypes between patients and controls. There were no significant differences in serum glucose, insulin, lipoproteins, index HOMA, as well as BMI and waist circumference between patients with GlyArg and GlyGly. Both CC and TC/TT genotype patients had similar values of BMI, waist and measured biochemical variables. Moreover, Gly972Arg and C825T polymorphisms were not related to hormonal status of PCOS women.

Conclusion. The Gly972Arg and C825T polymorphisms are associated neither with PCOS nor with metabolic syndrome in the Slovak female population.

Keywords:

• Polycystic ovary syndrome
• polymorphism
• IRS-1 Gly972Arg
• GNB3 C825T
• insulin resistance

Acknowledgements

This work is supported by Agency of the Ministry of Education of the Slovak Republic for the Structural Funds of the European Union, Operational Programme Research and Development (OP R&D), Contract No: 005/2009/2.1/ OP R&D.