Thrombocytosis secondary to chronic lead poisoning

Abstract

We report a case of total hyperpigmentation of the skin, severe itching, muscle weakness and thrombocytosis. Laboratory investigation showed white blood cell (WBC) 8.2 × 10⁶/L, Hb 125 g/L, platelets 1221 × 10⁶/L and urinary lead after DMSA mobilization test 2684 mcg/g creatinine (normal <5). Chelation therapy with DMSA resulted in complete recovery of the hyperpigmentation, itching and thrombocytosis. Lead poisoning should be considered in the differential diagnosis of obscured thrombocytosis.

• Lead poisoning
• thrombocytosis
• DMSA
• severe itching
• chelation therapy

Acknowledgment

We acknowledge Prof. AMA Gader for his critical review of this article.