Activated platelet chemiluminescence and presence of CD45+ platelets in patients with acute myocardial infarction

Abstract

It has been found that in 15% of acute myocardial infarction patients’ platelets generate reactive oxygen species that can be detected with luminol-enhanced chemiluminescence of platelet-rich plasma within 8–10 days after acute myocardial infarction. This increase in generate reactive oxygen species production coincides with the emergence of CD45⁺ platelets. The ability of platelets to carry surface leukocyte antigen implies their participation in exchange of specific proteins in the course of acute myocardial infarction. Future studies of CD45⁺ platelets in peripheral blood of acute myocardial infarction patients in association with generate reactive oxygen species production may provide a new insight into the complex mechanisms of cell–cell interactions associated with acute myocardial infarction.

• Acute myocardial infarction
• chemiluminescence
• CD45
• platelets

Acknowledgements

The authors are grateful to Dr Leonid Margolis for his constructive criticism. We are grateful to Dr Alexey Yavlinsky and Dr Barry Alpher for assistance in editing and improving the English style.

Notice of correction:

Following initial Early Online publication, grant numbers were added by request of the authors.