Economic evaluation of biologic therapies for the treatment of moderate to severe psoriasis in the United States

Abstract

Background: New biologic therapies are available for moderate to severe psoriasis. Objective: To determine the most cost-effective sequence of biologic treatments. Methods: Through modeling of the clinical pathway of biologic agents, adalimumab, alefacept, efalizumab, etanercept, and infliximab, the costs and benefits (quality-adjusted life-years [QALYs]) were determined. A decision rule determined the optimal treatment sequence comparing costs and QALYs. Results: While infliximab was found to provide the most incremental QALY and etanercept was found to be the least costly, on balance, the incremental cost-effectiveness ratio of adalimumab was the most favorable (ICER = $544/QALY). Consequently, the optimal sequence would begin with adalimumab and be followed by etanercept, infliximab, efalizumab, and alefacept, respectively. The limitations of this study are that evidence was based on indirect comparisons of biologic effectiveness, and toxicities were not included in the model. Conclusions: In consideration of cost-effectiveness in prescribing biologics for moderate to severe psoriasis, the optimal sequence would begin with adalimumab.

Key words::

• biologics
• cost-effectiveness
• economics
• QALYs
• TNF antagonist

Acknowledgements

The authors acknowledge the support of Tracey Fine, MS, ELS, of Fine Biomedical Publications, Inc., Chapel Hill, NC, and Michael Nissen, ELS, of Abbott Laboratories, Abbott Park, IL, in editing this manuscript. This analysis was supported by Abbott Laboratories, Abbott Park, IL, USA.

Declaration of interest: Dr Anis has received grants from Abbott, Wyeth and Schering Plough and received honoraria from Wyeth. Sonia Sizto and NickBansback were employed to work on this project but were not the PI and do not have anything else to declare. Dr Feldman owns stock or stock options in Medical Quality Enhancement Company and Photomedex. He has received grants from Abbott, Galderma, Astellas, and Warner Chilcott and has received honoraria from Abbott, Centocor, Genentech, Amgen, Warner Chilcott, Astellas, Suncare, Galderma, Stiefel, Doak, and Novartis. Dr Gupta is an Abbott employee. Dr Willian was an Abbott employee at the time that this paper was being written.