Acknowledgement
François Aubin and Philippe Humbert are coinvestigators in clinical trials for Schering-Plough, Merck-Serono, Abbott and Wyeth. François Aubin is a consultant for Abbott, Schering-Plough, Merck-Serono and Wyeth. Fabien Pelletier, Eve Puzenat and François Aubin have been invited consultants and auditors for conferences with Abbott, Schering- Plough, Merck-Serono and Wyeth. Clarisse Saccomani, Séverine Penz, Raphaelle Guerre-Schmidt and Marie-Odile Riou-Gotta report no conflict of interest.