Wheat aleurone fractions and plasma n−3 fatty acids in rats

Abstract

The main aim of this study was to compare the effects of two wheat aleurone (WA) fractions on circulating n−3 fatty acids in rats. We demonstrated that only the fraction able to induce the highest urinary excretion of polyphenol metabolites (>1µmol) resulted in a significant increase in plasma level of Eicosapentanoic acid (+22%, p < 0.05). While other constituents of whole wheat can be involved in this response, our data suggest that cereals containing high levels of phenolic compounds can increase blood n−3 without affecting n−6 fatty acids. Further studies are required to confirm this hypothesis and explore the underlying biological mechanisms.

• n−3 long chain fatty acids
• phenolic acids
• wheat aleurone

Declaration of interest

Ounnas, Demeilliers, Calani, Hazane-Puch and Laporte have no conflicts of interest. Salen and de Lorgeril (through Grenoble University School of Medicine), Del Rio and Scazzina (through Parma University) disclose receiving research grants from the Barilla G&R F.lli Company. Melegari is an employee of Barilla G. R. Fratelli Spa.

This project has been funded by Barilla G. R. Fratelli Spa and supported in part by the 7th ATHENA Framework Program [Grant agreement No.: 245121] from the European Community.