A 12-week randomized double-blind parallel pilot trial of Sinetrol XPur on body weight, abdominal fat, waist circumference, and muscle metabolism in overweight men

Abstract

Overweight and obesity are associated to increased risk of developing non-communicable diseases that might dramatically affect life expectancy according World Health Organization. Overweight, obesity, and decline in physical activity are correlated to a significant propensity to lose skeletal muscle mass as a result of prolonged inflammation and oxidative stress whereas cohort surveys and clinical investigations have demonstrated health benefits of Citrus-based polyphenols to reverse such regression. Overweight men were included in a double-blind, randomized, parallel pilot trial where they received daily for a 12-week period 900 mg of a Citrus-based polyphenol extract, Sinetrol® XPur. Body composition, anthropometric, and blood parameters were assessed before and at the end of the intervention period. After 12 weeks, while the silhouette slimmed down, metabolic parameters were significantly improved and skeletal muscle catabolism held back. These data suggest that over a 12-week period, the efficacy of the supplement improve both overweight process and correlated skeletal muscle mass metabolism.

• Abdominal fat
• inflammation
• insulin resistance
• obesity
• polyphenols
• weight loss

Declaration of interest

Fytexia is involved in the research, development, marketing, and sales of polyphenolic extracts from various fruit and vegetables regularly consumed within the Mediterranean diet for food and nutraceutical industries. Therefore, Fytexia has a commercial interest in this publication. RDVC was paid by Fytexia to conduct the clinical investigation and perform the clinical and biochemical measurements forming the basis of this publication. UMR 204 NUTRIPASS examined raw data to determine health benefits and hypotheses. Fytexia, RDVC, and UMR 204 NUTRIPASS declare that the data in this report represent a true and faithful representation of the work that has been performed. The financial assistance of Fytexia is gratefully acknowledged.