Rapid cycling bipolar affective disorder and recurrent strokes secondary to high blood homocysteine

Abstract

Introduction: The interface between psychiatric disorders and organicity has been a matter for contentious debate.

Aim: To report an interesting clinical case of moderate homocystinuria presenting with significant psychiatric and neurological deficits.

Method: A case report highlighting the impact of homocystinuria on producing intractable rapid cycling bipolar affective disorder.

Discussion: Homocystinuria is a frequently missed cause for treatment-resistant bipolar affective disorder.

• homocystinuria
• bipolar affective disorder
• recurrent strokes

Acknowledgements

MA and SZ had seen the patient and examined him and obtained the relevant history. ME was responsible for interpreting the biochemical results of the patient. MA and ME prepared the manuscript and all authors reviewed and edited the manuscript and approved the final version of the manuscript.