Streptomyces nucleases

Abstract

Streptomyces nucleases are widely distributed and multifunctional enzymes acting on both DNA and RNA. They occur extra as well as intracellularly and can be classified under sugar specific and sugar non-specific nucleases. Nucleases play different roles like analytical, biological, and nutritional. They are also used in programmed cell death. Although more than 20 nucleases are reported to date, very little information is available regarding their structure-function relationship, active site based sequence homology, and the probable mechanism of action. This review describes the history, occurrence, localization, production, purification, properties, and applications of Streptomyces nucleases.

Keywords::

• Endonuclease
• extracellular
• production
• purification
• substrate specificity
• applications

Acknowledgment

We thank Mr.Vaibhav Mahindarkar for his help in the preparation of manuscript. This article is not included in your organization′s subscription. However, you may be able to access this article under your organization′s agreement with Elsevier.

Declaration of interest

The authors report no conflict of interest. The authors alone are responsible for the content and writing of the article