Association of genetic variations in mTOR with risk of childhood acute lymphoblastic leukemia in a Chinese population

Abstract

The mammalian target of rapamycin (mTOR) is an important protein kinase regulating cell survival and apoptosis. To determine whether genetic variations in mTOR are associated with risk of acute lymphoblastic leukemia (ALL) in Chinese children, we genotyped two tag single nucleotide poymorphisms (SNPs) in mTOR (rs2536 and rs2295080) in a case–control study. We observed that the variant genotype TC of mTOR rs2536 was associated with a significantly decreased risk of childhood ALL (adjusted odds ratio [OR] = 0.67, 95% confidence interval [CI] = 0.46–0.96), and the association was more pronounced in high-risk ALL and T-phenotype ALL groups. Additionally, we found that the combined genotypes TC/CC decreased the risk of ALL only in the high-risk ALL group (adjusted OR = 0.54, 95% CI = 0.32–0.91) and T-phenotype ALL group (adjusted OR = 0.29, 95% CI = 0.10–0.84). These results suggest that the mTOR rs2536 polymorphism is involved in the susceptibility to childhood ALL in a Chinese population.

Keywords::

• Childhood
• acute lymphoblastic leukemia
• mTOR

Acknowledgements

This research was partly supported by the National Natural Science Foundation of China (81070436) and the Nanjing Special Foundation for Medical Science (ZKM05039).

Potential conflict of interest:

Disclosure Disclosure forms provided by the authors are available with the full text of this article at www.informahealthcare.com/lal.