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Leukemia & Lymphoma Volume 56, 2015 - Issue 5
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The 8th Young Investigators' Meeting on Chronic Lymphocytic Leukemia Article

Nurse like cells: chronic lymphocytic leukemia associated macrophages

Frédéric BoissardINSERM UMR1037 – Cancer Research Center of Toulouse, Toulouse, France;Université Toulouse III Paul-Sabatier, Toulouse, France;ERL 5294 CNRS, BP3028, Hospital Purpan, Toulouse, France
,
Jean-Jacques FourniéINSERM UMR1037 – Cancer Research Center of Toulouse, Toulouse, France;Université Toulouse III Paul-Sabatier, Toulouse, France;ERL 5294 CNRS, BP3028, Hospital Purpan, Toulouse, France
,
Camille LaurentUniversité Toulouse III Paul-Sabatier, Toulouse, France;Department of Hematology, Centre Hospitalier Universitaire de Toulouse Purpan, Toulouse, France;INSERM UMR1043 – Center of Physiopathology of Toulouse Purpan, Toulouse, France
,
Mary PoupotINSERM UMR1037 – Cancer Research Center of Toulouse, Toulouse, France;Université Toulouse III Paul-Sabatier, Toulouse, France;ERL 5294 CNRS, BP3028, Hospital Purpan, Toulouse, France
&
Loïc YsebaertINSERM UMR1037 – Cancer Research Center of Toulouse, Toulouse, France;Université Toulouse III Paul-Sabatier, Toulouse, France;ERL 5294 CNRS, BP3028, Hospital Purpan, Toulouse, France;Department of Hematology, Centre Hospitalier Universitaire de Toulouse Purpan, Toulouse, FranceCorrespondence[email protected]
Pages 1570-1572 | Received 11 Nov 2014, Accepted 16 Nov 2014, Published online: 11 Feb 2015
 
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Abstract

CD14 + cells are able to differentiate into large and adherent cells if in contact with chronic lymphocytic leukemia (CLL) cells or healthy B lymphocytes. In CLL these cells, called CLL-nurse like cells (NLCs), express a very high amount of CD163 and CD68 and are able to rescue CLL cells through CCL4 production. Adherent cells derived from healthy donors, called HD-NLCs, express very little CD163 and CD68, do not produce CCL4 and are unable to rescue CCL cells. This study reveals that CLL-NLCs are the specific nurse cells in CLL, protecting CLL cells from death.

Potential conflict of interest

Disclosure forms provided by the authors are available with the full text of this article at www.informahealthcare.com/lal.

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