BP1 overexpression is associated with adverse prognosis in de novo acute myeloid leukemia

Abstract

To investigate DLX4 isoforms expression and their clinical significance in acute myeloid leukemia (AML). DLX4 transcript variant 1 (BP1) expression was significantly up-regulated in AML patients compared with normal controls. However, DLX4 transcript variant 2 (DLX7) was significantly down-regulated in AML patients. Both in the overall AML and the non-M3 AML cohorts, those patients with high BP1 expression (BP1^high) showed significantly lower rates of complete remission than those with low BP1 expression (BP1^low). BP1^high cases had significantly shorter overall survival than BP1^low cases in the overall AML cohort, non-M3 AML, and cytogenetically normal AML (CN-AML). Multivariate analysis confirmed the independent prognostic value of BP1 expression among both the overall AML cohort and non-M3 AML as well as CN-AML patients. However, we did not observe the impact of DLX7 expression on prognosis in AML patients. Our study reveals that BP1 overexpression serves as an independent risk factor in de novo AML patients.

Keywords:

• Acute myeloid leukemia
• BP1
• DLX4
• DLX7
• expression
• prognosis

Acknowledgements

This study was supported by the National Natural Science Foundation of China [81270630, 81172592], Science and Technology Special Project in Clinical Medicine of Jiangsu Province [BL2012056], 333 Project of Jiangsu Province [BRA2013136], Science and Technology Infrastructure Program of Zhenjiang [SS2012003], Medical Key Talent Project of Zhenjiang, Social Development Foundation of Zhenjiang [SH2013042, SH2013082, SH2014044, SH2014086].

Potential conflict of interest

Disclosure forms provided by the authors are available with the full text of this article at http://dx.doi.org/10.3109/10428194.2015.1088648.