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Leukemia & Lymphoma Volume 57, 2016 - Issue 6
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Original Articles: Research

A prospective analysis of blood donation history and risk of non-Hodgkin lymphoma

Kazusa IshiiHematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA,
,
Brenda M. BirmannChanning Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA,
,
Xuehong ZhangChanning Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA,
,
Edward GiovannucciChanning Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA, ;Department of Epidemiology, and ;Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA
&
Kimberly A. BertrandChanning Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA, ;Department of Epidemiology, and Correspondence[email protected]
Pages 1423-1428 | Received 04 May 2015, Accepted 30 Aug 2015, Published online: 16 Oct 2015
 
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Abstract

Blood donation may influence subsequent NHL development via temporary immune system alterations. To test the hypothesis that frequent blood donation is associated with an increased risk of NHL and its most common histologic subtypes, this study followed 36 576 men in the Health Professionals Follow-up Study (HPFS), who provided information on frequency of blood donation in the past 30 years in 1992. This study confirmed 544 incident cases of NHL through 2010. Cox proportional hazards regression was used to calculate hazards ratios (HR) and 95% CI for the risk of all NHL and major NHL histologic subtypes associated with number of blood donations. In this prospective study, there was no significant evidence of an association between blood donation frequency and incidence of NHL (age-adjusted HR = 1.26, 95% CI = 0.94–1.68, comparing > 20 donations vs 0 donations over 30 years, p for trend = 0.18) or of any major NHL subtypes.

Acknowledgments

The authors thank the participants and staff of the HPFS for their valuable contributions as well as the following state cancer registries for their help: AL, AZ, AR, CA, CO, CT, DE, FL, GA, ID, IL, IN, IA, KY, LA, ME, MD, MA, MI, NE, NH, NJ, NY, NC, ND, OH, OK, OR, PA, RI, SC, TN, TX, VA, WA and WY. The authors assume full responsibility for analyses and interpretation of these data. This work was supported by the NIH (CA055075, CA167552 and CA149445) and the American Cancer Society (RSG-11-020-01-CNE). K. A. Bertrand was supported by the Simeon J. Fortin Charitable Foundation, Bank of America, N.A., Co-Trustee.

Potential conflict of interest

Disclosure forms provided by the authors are available with the full text of this article at http://dx.doi.org/10.3109/10428194.2015.1091928

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