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Leukemia & Lymphoma Volume 57, 2016 - Issue 4
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Original Articles: Clinical

Evaluation of geriatric assessment in patients with chronic lymphocytic leukemia: Results of the CLL9 trial of the German CLL study group

Valentin GoedeGerman CLL Study Group, Department I of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University Hospital Cologne, Cologne, Germany, ;Department of Geriatric Medicine, St Marien Hospital, Cologne, Germany, Correspondence[email protected]
,
Jasmin BahloGerman CLL Study Group, Department I of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University Hospital Cologne, Cologne, Germany,
,
Viktoria ChatalineGerman CLL Study Group, Department I of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University Hospital Cologne, Cologne, Germany,
,
Barbara EichhorstGerman CLL Study Group, Department I of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University Hospital Cologne, Cologne, Germany,
,
Jan DürigDepartment of Hematology, University Hospital Essen, Essen, Germany,
,
Stephan StilgenbauerDepartment III of Internal Medicine, University Hospital Ulm, Ulm, Germany,
,
Gerald KolbDepartment of Geriatric Medicine, Bonifatius Hospital, Lingen, Germany,
,
Friedemann HoneckerDepartment of Oncology, Hematology, Bone Marrow Transplantation with section Pneumology, University Hospital Hamburg-Eppendorf, Hamburg, Germany, ;Tumor and Breast Center ZeTuP, St. Gallen, Switzerland,
,
Ulrich WeddingDepartment II of Internal Medicine, University Hospital Jena, Jena, Germany, and
&
Michael HallekGerman CLL Study Group, Department I of Internal Medicine, Center of Integrated Oncology Cologne-Bonn, University Hospital Cologne, Cologne, Germany, ;Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), University of Cologne, Cologne, Germany
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Pages 789-796 | Received 14 Jul 2015, Accepted 29 Aug 2015, Published online: 13 Oct 2015
 
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Abstract

Multidimensional geriatric assessment (GA) has been demonstrated to predict outcomes in older patients with cancer. This study evaluated GA in a cohort of older patients with chronic lymphocytic leukemia (CLL). Seventy-five of 97 subjects with CLL who were enrolled in a clinical trial of the German CLL Study Group underwent GA prior to the start of study treatment (low-dose chemotherapy with fludarabine). GA included cumulative illness rating scale (CIRS), timed-up-and-go (TUG) test, dementia detection (DEMTECT) test and instrumental activities of daily living (IADL) index. There was little correlation between CIRS, TUG, DEMTECT or IADL results and treatment toxicity, feasibility or efficacy in this study. CIRS and IADL had no statistically significant impact on overall prognosis. However, under-performance in TUG or DEMTECT test was strongly associated with poor survival. The latter findings provide a rationale to further investigate geriatric assessment in CLL and in the context with other CLL treatments.

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