Advanced search
Publication Cover
Leukemia & Lymphoma Volume 57, 2016 - Issue 10
Submit an article Journal homepage
394
Views
5
CrossRef citations to date
0
Altmetric
Original Articles: Clinical

Romidepsin in relapsed/refractory T-cell lymphomas: Italian experience and results of a named patient program

Pier Luigi ZinzaniInstitute of Hematology “L. E A. Seràgnoli”, University of Bologna, Bologna, Italy; Correspondence[email protected]
,
Cinzia PellegriniInstitute of Hematology “L. E A. Seràgnoli”, University of Bologna, Bologna, Italy;
,
Giuseppe CercielloAOU Policlinico Federico II, Napoli, Italy;
,
Federico MonacoA.O. SS Antonio E Biagio E Cesare Arrigo, Alessandria, Italy;
,
Stefano VolpettiCentro Trapianti E Terapie Cellulari Azienda Ospedaliero-Universitaria, Udine, Italy;
,
Annalisa PeliDepartment of Hematology, Spedali Civili, Brescia, Italy;
,
Emanuele AngelucciUO Ematologia E Centro Trapianti, Ospedale Oncologico Di Riferimento Regionale “Armando Businco”, Azienda Ospedaliera “Brotzu”, Cagliari, Italy;
,
Paolo CorradiniIstituto Nazionale Dei Tumori, Università Di Milano, Milano, Italy;
,
Maria Christina CoxHematology Unit, Sant'andrea Hospital, Roma, Italy;
,
Attilio GuariniNatl Cancer Center “Istituto Tumori Giovanni Paolo II IRCCS”, Bari, Italy;
,
Maurizio MussoOncohematology and Bone Marrow Unit, Oncology Department, La Maddalena, Palermo, Italy;
,
Paola BrescianiDepartment of Medical and Surgical Sciences, UNIMORE, AOU Policlinico, Modena, Italy;
,
Gabriella AmatoOncology and Hematology Department, IOM Istituto Oncologico Del Mediterraneo, Viagrande, Catania, Italy;
,
Atto BillioHematology and BMT, Central Hospital, Bolzano, Italy;
,
Giuseppe CaparrottiDivision of Hematology, San Giuseppe Moscati Hospital, Aversa, Caserta, Italy;
,
Amalia FigueraDivision of Hematology, AOU Policlinico-Vittorio Emanuele, Catania, Italy;
,
Luca NassiDivision of Hematology, Department of Translational Medicine Amedeo Avogadro University of Eastern Piedmont and Maggiore Hospital, Novara, Italy;
,
Francesco GaudioDepartment of Emergency and Organ Transplantation (D.E.T.O.), Hematology Section, University of Bari, Bari, Italy;
,
Alberto GrossiIstituto Fiorentino Di Cura E Assistenza, Firenze, Italy;
,
Francesco OnidaOnco-Hematology, BMT Center Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico University of Milan, Milano, Italy;
,
Michele MerliOspedale Di Circolo, Fondazione Macchi, University Hospital, Varese, Italy;
,
Luigi RigacciHematology Department AOU Careggi, Firenze, Italy
&
Lisa ArgnaniInstitute of Hematology “L. E A. Seràgnoli”, University of Bologna, Bologna, Italy;
show all
Pages 2370-2374 | Received 01 Nov 2015, Accepted 25 Dec 2015, Published online: 17 Feb 2016
 
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

Abstract

Clinical trial results indicate that romidepsin, a histone deacetylase inhibitor, is a promising treatment in relapsed/refractory T-cell lymphomas (TCLs). This retrospective multicenter study was conducted in patients with relapsed/refractory TCL treated with romidepsin monotherapy through a Named Patient Program (NPP) in Italy. Principal endpoints were overall response rate (ORR), safety, and overall survival (OS). The ORR in 33 evaluable patients was 24.2% with an ORR in the cutaneous TCL of 35.7%. Global OS was 39.3% at 30 months. There were not any specific differences on hematological and extrahematological adverse events. Data from patients treated with romidepsin outside a controlled clinical trial give additional information about the clinical use, efficacy, and toxicity of the drug given to relapsed or refractory TCL patients in a real life context as TCLs are rare diseases and more information is needed. These findings suggest that romidepsin is effective and safe for heavily pretreated TCL patients.

Potential conflict of interest

Disclosure forms provided by the authors are available with the full text of this article at http://dx.doi.org/10.3109/10428194.2015.1137292.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,065.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.