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Biotechnic & Histochemistry Volume 88, 2013 - Issue 7: Post-transcriptional processing in neoplasia. Guest Editor: William Grizzle
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Research Article

MicroRNAs as potential clinical biomarkers: emerging approaches for their detection

SK SrivastavaMitchell Cancer Institute, University of South Alabama, Mobile
,
A BhardwajMitchell Cancer Institute, University of South Alabama, Mobile
,
SJ LeavesleyDepartment of Chemical and Biomolecular Engineering, University of South Alabama, Mobile;Department of Pharmacology, University of South Alabama, Mobile
,
WE GrizzleDepartment of Pathology, University of Alabama at Birmingham, Birmingham
,
S SinghMitchell Cancer Institute, University of South Alabama, Mobile
&
AP SinghMitchell Cancer Institute, University of South Alabama, Mobile;Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, AlabamaCorrespondence[email protected]
Pages 373-387 | Published online: 07 Jan 2013
 
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Abstract

MicroRNAs (miRNAs) have emerged as novel post-transcriptional regulators of gene expression. These short non-coding RNAs are involved in diverse biological processes and their dysregulation is often observed under diseased conditions. Therefore, miRNAs hold great potential as clinical biomarkers of physiological and pathological states and extensive efforts are underway to develop efficient approaches for their detection. We review recent advances and discuss the promises and pitfalls of emerging methods of miRNA profiling and detection.

Acknowledgments

This research was funded by NIH/NCI (CA137513), DOD/US Army (PC0739930, PC093309) and USAMCI.

Conflict of interest statement: The authors have no potential conflict of interest to disclose.

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