Polybutylcyanoacrylate nanocarriers as promising targeted drug delivery systems

Abstract

Among the materials for preparing the polymeric nanocarriers, poly(n-butylcyanoacrylate) (PBCA), a polymer with medium length alkyl side chain, is of lower toxicity and proper degradation time. Therefore, PBCA has recently been regarded as a kind of widely used, biocompatible, biodegradable, low-toxic drug carrier. This review highlights the use of PBCA-based nanocarriers (PBCA-NCs) as targeting drug delivery systems and presents the methods of preparation, the surface modification and the advantages and limitations of PBCA-NCs. The drugs loaded in PBCA-NCs are summarized according to the treatment of diseases, and the different therapeutic applications and the most recent developments of PBCA-NCs are also discussed, which provides useful guidance on the targeting research of PBCA-NCs.

• Pharmaceutical applications
• poly(butylcyanoacrylate)
• polymeric nanocarriers
• targeted drug delivery

Declaration of interest

The authors report no declarations of interest. The authors alone are responsible for the content and writing of the paper. This work was supported by the Natural Science Foundation of Jiangsu Province (Program No. BK20130655, No. BK2012761), and College Students Innovation Project for the R&D of Novel Drugs (Program No. J1030830) and the National College Students' innovation entrepreneurial training program (Program No. G12097).