Preeclampsia and Risk of Developing Subsequent Diabetes

Abstract

Objective: Determine whether preeclampsia is associated with developing diabetes. Methods: Subsequent diabetes was ascertained using ICD-9 codes, pharmacy and glucose data in a retrospective cohort study of 2,032 women with preeclampsia and 29,431 without preeclampsia. Results: During a median follow-up of 8.2 years, 342 women developed diabetes. Preeclampsia was associated with a higher risk of diabetes adjusting for age, primigravidity, and gestational diabetes (hazard ratio, HR 1.82, 95%CI 1.26, 2.62) and in women without gestational diabetes (n = 30,109; HR 1.86, 95%CI 1.22, 2.84). Conclusion: Women with preeclampsia have greater risk of developing diabetes, even in the absence of gestational diabetes.

Keywords:

• Preeclampsia
• Gestational diabetes
• Diabetes
• Epidemiology

ACKNOWLEDGMENTS

This work was supported by the Washington State Obstetrical Association, the National Institutes of Health Grants K23RR16066 and K30RR022293 from the National Center for Research Resources, and the Department of Veterans Affairs.

We thank Walter Clinton for his expertise in the acquisition of the automated data.

Declaration of Interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this paper.