Gestational Diabetes or Lesser Degrees of Glucose Intolerance and Risk of Preeclampsia

Abstract

Objective. We evaluated the association of 1-h oral glucose challenge test (OGCT) and 3-h oral glucose tolerance test (OGTT) results with preeclampsia. Methods. A retrospective cohort study was performed among 26,105 women. Results. Preeclampsia was associated with the upper OGCT quartiles [114–132 mg/dL: odds ratio (OR) = 1.25, 95% confidence interval (CI) 1.09–1.44; >132 mg/dL: OR = 1.40, 95% CI 1.21–1.61] compared with <98 mg/dL adjusting for age, primigravidity, and gestational diabetes, and also to one abnormal OGTT value (adjusted OR 1.38, 95% CI 1.09–1.75) or gestational diabetes (adjusted OR 1.45, 95% CI 1.15–1.83). Conclusion. Higher glucose levels are associated with preeclampsia suggesting a pathophysiological role for glucose metabolism.

• Gestational diabetes
• Glucose tolerance
• Preeclampsia

ACKNOWLEDGMENTS

The authors thank Walter Clinton for his expertise in the acquisition of the automated data.

Funding. This work was supported by the Washington State Obstetrical Association, the National Institutes of Health Grants K23RR16066 and K30RR022293 from the National Center for Research Resources and the Department of Veterans Affairs.

Declaration of Interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.